ASSESSING THE IMPACT OF LOW-DOSE ASPIRIN ON CARDIOVASCULAR DISEASE PREVENTION IN DIABETIC PATIENTS

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Heena Jilani
Naheed Shah
Anurag Rawat
Sahil Sajjad
Hafiz Moazam Hussain
Muhammad Arshad Malik

Abstract

Background: Diabetes significantly increases the risk of cardiovascular disease (CVD), prompting interest in preventive treatments such as low-dose aspirin. Despite its potential, the efficacy of aspirin in this context remains debated.


Objective: This study aimed to evaluate the effectiveness of low-dose aspirin in preventing CVD among individuals with type 2 diabetes.


Methods: In this double-blind, placebo-controlled, randomized trial, 100 type 2 diabetic patients without previous CVD were enrolled. Participants were randomly assigned to receive either 81 mg/day of aspirin or a placebo for one year. The primary endpoint was the incidence of major adverse cardiovascular events (MACE).


Results: Each group comprised 50 participants with comparable baseline characteristics. The incidence of MACE was 10% in the aspirin group compared to 28% in the placebo group, achieving statistical significance (p=0.03). While the aspirin group also showed reductions in myocardial infarction and stroke, these differences were not statistically significant.


Conclusion: Low-dose aspirin significantly reduces the incidence of MACE in type 2 diabetic patients, supporting its use as a preventive intervention in this high-risk group.

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Author Biographies

Heena Jilani, Ziauddin University, Karachi, Pakistan.

Ziauddin University, Karachi, Pakistan.

Naheed Shah, University of Sindh Jamshoro, Pakistan..

Department of Zoology, University of Sindh, Jamshoro, Pakistan.

Anurag Rawat, Himalayan institute of medical science jolly Grant Dehradun India.

Department of cardiology, Himalayan institute of medical science, jolly Grant, Dehradun, India.

Sahil Sajjad, Rehabilitation Centre Hayatabab medical complex Peshawar, Pakistan.

RN Cardiac Rehabilitation Centre Hayatabab medical complex Peshawar, Pakistan.

Hafiz Moazam Hussain, Health services academy Islamabad, Pakistan.

Health services academy Islamabad, Pakistan.

Muhammad Arshad Malik, Hematology Holy Family Hospital Rawalpindi, Pakistan.

Hematology Holy Family Hospital Rawalpindi, Pakistan.