COMPARISON OF PROLOTHERAPY AND DRY NEEDLING ONPAIN, DISABLITY, RANGE OF PASSIVE STRAIGHT LEG RAISINGAND KINESIOPHOBIA IN PATIENT WITH CHRONIC SCIATIC PAIN
DOI:
https://doi.org/10.71000/wajnze70Keywords:
Dry Needling; Kinesiophobia; Low Back Pain; Pain Measurement; Prolotherapy; SciaticaAbstract
Background: Chronic sciatic pain can substantially affect pain, mobility, disability, and fear of movement. Prolotherapy and dry needling are used as interventional or adjunctive approaches for persistent musculoskeletal pain, but direct comparative evidence in chronic sciatica is limited.
Objective: To compare the effects of prolotherapy and dry needling on pain, disability, passive straight leg raise, and kinesiophobia in patients with chronic sciatic pain.
Methods: This single-blind randomized clinical trial recruited 40 adults aged 20–50 years with unilateral chronic sciatic pain from three hospitals in Lahore. Participants were allocated by a random-number generator to prolotherapy plus therapeutic ultrasound (n=20) or dry needling plus the same ultrasound protocol (n=20). Six intervention sessions were delivered at 15-day intervals. Outcomes were the Oswestry Disability Index (ODI), Tampa Scale of Kinesiophobia (TSK), Numeric Pain Rating Scale (NPRS), and passive straight leg raise (SLR). Paired-samples t tests assessed within-group change. Between-group differences in change scores were evaluated using independent-samples tests, and 95% confidence intervals were calculated from the available summary statistics.
Results: All 40 randomized participants completed follow-up and were analyzed. Both groups showed significant within-group improvement in ODI, TSK, NPRS, and SLR (all p<0.001). Compared with dry needling, prolotherapy produced greater mean improvement in ODI (mean difference [MD] 3.23 points, 95% CI 1.28–5.18; p=0.002), TSK (MD 3.57 points, 95% CI 0.36–6.78; p=0.031), and SLR (MD 2.06°, 95% CI 0.64–3.48; p=0.006). The between-group difference in NPRS improvement was not significant (MD 0.27 points, 95% CI −1.11 to 1.65; p=0.694).
Conclusion: Both prolotherapy and dry needling, when combined with therapeutic ultrasound, were associated with improvement in pain, disability, kinesiophobia, and passive SLR. Prolotherapy showed larger improvements in disability, kinesiophobia, and SLR, while pain reduction was similar between groups. These findings should be interpreted in the context of the small sample and short-term trial design.
Keywords: Dry Needling; Kinesiophobia; Low Back Pain; Pain Measurement; Prolotherapy; Sciatica
References
GBD 2021 Low Back Pain Collaborators. Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5(6):e316–e329. doi:10.1016/S2665-9913(23)00098-X.
Peene L, Cohen SP, Kallewaard JW, Wolff A, Huygen F, van de Gaag A, et al. Lumbosacral radicular pain. Pain Pract. 2024;24(3):525–552. doi:10.1111/papr.13317.
Khorami AK, Oliveira CB, Maher CG, Bindels PJE, Machado GC, Pinto RZ, et al. Recommendations for diagnosis and treatment of lumbosacral radicular pain: a systematic review of clinical practice guidelines. J Clin Med. 2021;10(11):2482. doi:10.3390/jcm10112482.
Dove L, Jones G, Kelsey LA, Cairns MC, Schmid AB. How effective are physiotherapy interventions in treating people with sciatica? A systematic review and meta-analysis. Eur Spine J. 2023;32(2):517–533. doi:10.1007/s00586-022-07356-y.
Liu C, Ferreira GE, Abdel Shaheed C, Chen Q, Harris IA, Bailey CS, et al. Surgical versus non-surgical treatment for sciatica: systematic review and meta-analysis of randomised controlled trials. BMJ. 2023;381:e070730. doi:10.1136/bmj-2022-070730.
Bae G, Kim S, Lee S, Lee WY, Lim Y. Prolotherapy for the patients with chronic musculoskeletal pain: systematic review and meta-analysis. Anesth Pain Med (Seoul). 2021;16(1):81–95. doi:10.17085/apm.20078.
Nazwar TA, Bal’afif F, Wardhana DW, Bal’afif F, Panjaitan C. Effectiveness and safety of dextrose prolotherapy for chronic spinal pain: a systematic review. J Anaesthesiol Clin Pharmacol. 2026;42(3):332–344. doi:10.4103/joacp.joacp_524_25.
Lara-Palomo IC, Gil-Martínez E, López-Fernández MD, González González LM, Querol-Zaldívar MA, Castro-Sánchez AM. Efficacy of dry needling for chronic low back pain: a systematic review and meta-analysis of randomized controlled trials. Altern Ther Health Med. 2023;29(8):110–120.
Mahmoudzadeh A, Rezaeian ZS, Karimi A, Dommerholt J. The effect of dry needling on the radiating pain in subjects with discogenic low-back pain: a randomized control trial. J Res Med Sci. 2016;21:86. doi:10.4103/1735-1995.192502.
Hopewell S, Chan AW, Collins GS, Hróbjartsson A, Moher D, Schulz KF, et al. CONSORT 2025 statement: updated guideline for reporting randomised trials. BMJ. 2025;389:e081123. doi:10.1136/bmj-2024-081123.
Saltychev M, Mattie R, McCormick Z, Bärlund E, Laimi K. Psychometric properties of the Oswestry Disability Index. Int J Rehabil Res. 2017;40(3):202–208. doi:10.1097/MRR.0000000000000226.
Dupuis F, Cherif A, Batcho C, Massé-Alarie H, Roy JS. The Tampa Scale of Kinesiophobia: a systematic review of its psychometric properties in people with musculoskeletal pain. Clin J Pain. 2023;39(5):236–247. doi:10.1097/AJP.0000000000001104.
Chiarotto A, Maxwell LJ, Ostelo RW, Boers M, Tugwell P, Terwee CB. Measurement properties of Visual Analogue Scale, Numeric Rating Scale, and Pain Severity subscale of the Brief Pain Inventory in patients with low back pain: a systematic review. J Pain. 2019;20(3):245–263. doi:10.1016/j.jpain.2018.07.009.
Nee RJ, Coppieters MW, Boyd BS. Reliability of the straight leg raise test for suspected lumbar radicular pain: a systematic review with meta-analysis. Musculoskelet Sci Pract. 2022;59:102529. doi:10.1016/j.msksp.2022.102529.
Chung MW, Hsu CY, Chung WK, Lin YN. Effects of dextrose prolotherapy on tendinopathy, fasciopathy, and ligament injuries, fact or myth? A systematic review and meta-analysis. Medicine (Baltimore). 2020;99(46):e23201. doi:10.1097/MD.0000000000023201.
Rajfur J, Rajfur K, Kosowski Ł, Walewicz K, Dymarek R, Ptaszkowski K, et al. The effectiveness of dry needling in patients with chronic low back pain: a prospective, randomized, single-blinded study. Sci Rep. 2022;12(1):15803. doi:10.1038/s41598-022-19980-1.
Loizidis T, Nikodelis T, Bakas E, Kollias I. The effects of dry needling on pain relief and functional balance in patients with sub-chronic low back pain. J Back Musculoskelet Rehabil. 2020;33(6):953–959. doi:10.3233/BMR-181265.
Amjad F, Mohseni-Bandpei MA, Gilani SA, Ahmad A, Hanif A. Effects of non-surgical decompression therapy in addition to routine physical therapy on pain, range of motion, endurance, functional disability and quality of life versus routine physical therapy alone in patients with lumbar radiculopathy: a randomized controlled trial. BMC Musculoskelet Disord. 2022;23(1):255. doi:10.1186/s12891-022-05196-x.
Maniquis-Smigel L, Reeves KD, Rosen HJ, Lyftogt J, Graham-Coleman C, Cheng AL, et al. Short term analgesic effects of 5% dextrose epidural injections for chronic low back pain: a randomized controlled trial. Anesth Pain Med. 2017;7(1):e42550. doi:10.5812/aapm.42550.
Price MR, Mead KE, Cowell DM, Troutner AM, Barton TE, Walters SA, et al. Medication recommendations for treatment of lumbosacral radiculopathy: a systematic review of clinical practice guidelines. PM R. 2024;16(10):1128–1142. doi:10.1002/pmrj.13142.
Yousif S, Musa A, Ahmed A, Abdelhai A. Correlation between findings in physical examination, magnetic resonance imaging, and nerve conduction studies in lumbosacral radiculopathy caused by lumbar intervertebral disc herniation. Adv Orthop. 2020;2020:9719813. doi:10.1155/2020/9719813.
World Health Organization. WHO guideline for non-surgical management of chronic primary low back pain in adults in primary and community care settings. Geneva: World Health Organization; 2023.
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Copyright (c) 2026 Dr. Muhammad Umar, Dr Hira Jabeen, Dr. Waqas Ashraf Chaudhry, Dr. Warda Shafique (Author)

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