PREVALENCE AND ASSOCIATED RISK FACTORS OF STROKE IN PATIENTS VISITED FOR COMPUTED TOMOGRAPHY (CT) BRAIN AT PESHAWAR

Authors

  • Muhammad Basit Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan. Author
  • Alia Wazir Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan. Author
  • Salman Khan Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan. Author
  • Muhammad Sohail Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan. Author
  • Abdul Salam Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan. Author
  • Abdul Wadood NCS University System Peshawar, Pakistan. Author

DOI:

https://doi.org/10.71000/rp2ehw44

Keywords:

Computed Tomography, , Prevalence, Risk Factors, Ischemic Stroke, Diabetes Mellitus, Hypertension, , Pakistan

Abstract

Background: Stroke continues to be a major global health challenge and is a leading cause of mortality and long-term disability, particularly in low- and middle-income countries such as Pakistan. Early recognition of associated risk factors is crucial for improving clinical outcomes and guiding targeted prevention strategies. Neuroimaging, especially computed tomography (CT) of the brain, plays an essential role in the prompt identification and classification of stroke subtypes.

Objective: To determine the prevalence and associated risk factors of stroke among patients who underwent CT brain imaging in public and private hospitals of Peshawar.

Methods: This descriptive cross-sectional study was conducted over six months, from January to June 2025, in radiology departments of tertiary care hospitals across Peshawar. A total of 323 patients aged 30 years and above, who presented with clinical suspicion of stroke, were included through non-probability consecutive sampling. Data were collected using a structured proforma covering demographic, clinical, and lifestyle variables. CT brain scans were interpreted to categorize stroke as ischemic, hemorrhagic, or subarachnoid hemorrhage. Statistical analysis was performed using IBM SPSS version 26. Descriptive statistics summarized demographic characteristics, while chi-square tests evaluated associations between stroke type and risk factors, with a significance threshold of p < 0.05.

Results: Out of 323 patients, males constituted 69.7%, and the majority (53.9%) were aged 46–60 years. Hypertension (44.9%) and diabetes mellitus (25.1%) were the most frequent comorbidities, while smoking (46.4%) and physical inactivity (46.4%) were the most common lifestyle risks. Ischemic stroke was detected in 66.3% of patients, followed by hemorrhagic stroke (26.9%) and subarachnoid hemorrhage (6.8%). Significant associations were found between stroke subtype and hypertension (p = 0.02), diabetes mellitus (p = 0.03), and smoking (p = 0.04).

Conclusion: The study demonstrates that stroke in Peshawar is predominantly ischemic and strongly linked with modifiable risk factors such as hypertension, diabetes, smoking, and physical inactivity. Preventive strategies emphasizing early detection, community-based education, and lifestyle modification are vital to reducing stroke incidence and improving outcomes in high-risk populations.

Author Biographies

  • Muhammad Basit, Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan.

    Department of Medical Imaging Technology, Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan.

  • Alia Wazir, Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan.

    Department of Medical Imaging Technology, Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan.

  • Salman Khan, Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan.

    Department of Medical Imaging Technology, Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan.

  • Muhammad Sohail, Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan.

    Department of Medical Imaging Technology, Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan.

  • Abdul Salam, Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan.

    Lecturer Medical Imaging Technology, Wazir Muhammad Institute of Allied Health Sciences, Gandhara University Peshawar, Pakistan.

  • Abdul Wadood, NCS University System Peshawar, Pakistan.

    Assistant Professor Radiology, NCS University System Peshawar, Pakistan.

References

Patel RJ, Willie-Permor D, Fan A, Zarrintan S, Malas MB. 30-Day Risk Score for Mortality and Stroke in Patients with Carotid Artery Stenosis Using Artificial Intelligence Based Carotid Plaque Morphology. Ann Vasc Surg. 2024;109:63-76.

Guo YJ, Gan XL, Zhang RY, Liu Y, Wang EL, Lu SH, et al. Acute ischemic stroke in tuberculous meningitis. Front Public Health. 2024;12:1362465.

Pommier T, Duloquin G, Pinguet V, Comby PO, Guenancia C, Béjot Y. Atrial fibrillation and preexisting cognitive impairment in ischemic stroke patients: Dijon Stroke Registry. Arch Gerontol Geriatr. 2024;123:105446.

Nutakki A, Chomba M, Chishimba LC, Zimba S, Gottesman RF, Bahouth MN, et al. Biological Sex Differences in Risk Factors and Outcomes Among Hospitalized Adults With Stroke in Lusaka, Zambia. Neurology. 2023;100(14):666-9.

Das AS, Gökçal E, Regenhardt RW, Warren AD, Biffi A, Goldstein JN, et al. Clinical and neuroimaging risk factors associated with the development of intracerebral hemorrhage while taking direct oral anticoagulants. J Neurol. 2022;269(12):6589-96.

Wang Y, Chen Y, Chen R, Xu Y, Zheng H, Xu J, et al. Development and validation of a nomogram model for prediction of stroke-associated pneumonia associated with intracerebral hemorrhage. BMC Geriatr. 2023;23(1):633.

Liberman AL, Lu J, Wang C, Cheng NT, Moncrieffe K, Lipton RB. Factors associated with hospitalization for ischemic stroke and TIA following an emergency department headache visit. Am J Emerg Med. 2021;46:503-7.

Gorski JK, Mithal DS, Mills MG, Ramgopal S. Factors Associated with Pathway-Concordant Neuroimaging for Pediatric Ischemic Stroke. J Pediatr. 2024;268:113905.

Huang Z, Cheng XQ, Lu RR, Bi XJ, Liu YN, Deng YB. Incremental Prognostic Value of Carotid Plaque-RADS Over Stenosis Degree in Relation to Stroke Risk. JACC Cardiovasc Imaging. 2025;18(1):77-89.

Truma A, Mancini I, Agosti P, Artoni A, Giannotta JA, Ferrari B, et al. Main features of ischemic stroke in patients with acute immune-mediated thrombotic thrombocytopenic purpura. Thromb Res. 2024;243:109151.

Lim JS, Lee KJ, Kim BJ, Ryu WS, Chung J, Gwak DS, et al. Nonhypertensive White Matter Hyperintensities in Stroke: Risk Factors, Neuroimaging Characteristics, and Prognosis. J Am Heart Assoc. 2023;12(23):e030515.

Fang S, Lei H, Ambler G, Werring DJ, Huang H, Lin H, et al. Novel CT Image-Based Intracerebral Bleeding Risk Score for Patients With Acute Ischemic Stroke Undergoing Thrombolysis. J Am Heart Assoc. 2025;14(4):e037256.

Karlin AR, Kumar NK, Vossough A, Abend NS, Ichord RN, Beslow LA. Pediatric Cerebral Sinovenous Thrombosis and Risk for Epilepsy. Pediatr Neurol. 2023;146:85-94.

Verburgt E, Fellah L, Ekker MS, Schellekens MMI, Boot EM, Immens MHM, et al. Risk of Poststroke Epilepsy Among Young Adults With Ischemic Stroke or Intracerebral Hemorrhage. JAMA Neurol. 2025;82(6):597-604.

Youkee D, Deen GF, Baldeh M, Conteh ZF, Fox-Rushby J, Gbessay M, et al. Stroke in Sierra Leone: Case fatality rate and functional outcome after stroke in Freetown. Int J Stroke. 2023;18(6):672-80.

Awan S, Sher K, Iltaf S, Panhwar Q. Frequency of ischemic stroke in patients with bacterial meningitis visiting to Jinnah Postgraduate Medical Center Karachi. Cross-sectional study. Romanian Journals of neurology. 2021 Jul 1; 20(3):364.

Elgammal TM, Fayed HA, El Shamy AM, Eltomy MA, Awwad MM. Risk factors, clinical presentation and 1-year outcome of ischemic stroke caused by small artery disease. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery. 2024 Jan 30; 60(1):13.

Namaganda P, Nakibuuka J, and Kaddumukasa M, Katabira E. Stroke in young adults, stroke types and risk factors: a case control study. BMC neurology. 2022 Sep 6; 22(1):335.

Mahmoud Z, Khan SU, Khan B, Shah SM, Khan A, Ali H, Ahmed SJ, Rehman MU, Nawaz H, Ulcsiqbal R. Management of Ischemic Stroke in a Tertiary Care Hospital in Khyber Pakhtunkhwa: Existing Status and Prospective Opportunities. Cureus. 2024 Jun 25; 16(6): e63094.

Jabeen SJ, Sadia M, Begum S, Khan MN. The Frequency of Depression in Post Stroke Patients presenting at Outpatient Department of Abbasi Shaheed Hospital, Karachi: Depression in Post Stroke Patients. Pakistan Journal of Health Sciences. 2023 Jun 30:231-5

Gan Y, Jiang H, Room R, Zhan Y, Li L, Lu K, Wang C, Chen S, Liu J, Yang Y, Xu H. Prevalence and risk factors associated with stroke in China: a nationwide survey of 726,451 adults. European journal of preventive cardiology. 2021 Nov 1; 28(12): e6-10.

Juli C, Heryaman H, Arnengsih, Ang ET, Defi IR, Gamayani U, Atik N. The number of risk factors increases the recurrence events in ischemic stroke. European Journal of Medical Research. 2022 Aug 2; 27(1):138.

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Published

2025-06-30