THE BIOLOGICAL POTENTIAL AND CHEMICAL ANALYSIS OF PHYSCIACEAE MEMBERS
DOI:
https://doi.org/10.71000/eeh62n09Keywords:
bioactive compounds, metabolites , Anti-inflammatory agents, Antimicrobial agents, Lichens, Physciaceae, Secondary metabolitesAbstract
Background: Lichens remain underexplored compared to higher plants, despite their rich repertoire of bioactive compounds with potential pharmaceutical, nutraceutical, and cosmeceutical applications. Within lichens, the Physciaceae family is the second largest after Parmeliaceae, yet only a small proportion of its members have been investigated for biological potential. Existing studies suggest that promising activities, including antimicrobial, antioxidant, cytotoxic, and anti-inflammatory effects, are present, but a comprehensive synthesis is lacking.
Objective: To systematically review and synthesize published data on the biological activities, chemical analyses, and bioactive compounds of Physciaceae species, highlighting research gaps and future directions.
Methods: A systematic search of Google Scholar, PubMed, Academic Search, BioOne, EMBASE, Europe PMC, CAB Abstracts, Golm Metabolome Database, Index Fungorum, and arXiv identified relevant studies published between 1989 and 2024. Inclusion criteria encompassed studies assessing bioactivity (e.g., antimicrobial, antioxidant, cytotoxic) of Physciaceae species and/or isolating and characterizing their chemical compounds. The extracted data included the species studied, reported bioactivities, analytical techniques employed, and identified compounds. In total, 93 eligible studies were included.
Results: Among ~25 genera in Physciaceae, only 15 species have undergone bioactivity testing. The most extensively studied genera were Anaptychia and Heterodermia. Antimicrobial activity was the most frequently reported (9 species, 8 compounds), followed by antioxidant (5 species, 6 compounds), cytotoxic (6 species, 1 compound), and anti-inflammatory (2 species, 2 compounds) effects. Techniques such as TLC, HPLC, GC-MS, LC-MS, and spectrophotometry identified compounds including atranorin, zeorin, lecanoric acid, flavonoids, fatty acids, and chlorophyll derivatives. Notably, several compounds demonstrated comparable potency to standard controls in antioxidant and antimicrobial assays.
Conclusion: Physciaceae lichens harbor diverse secondary metabolites with significant biological potential, yet most species remain unexamined. Expanded research using standardized methodologies and sustainable sampling is essential to unlock their therapeutic applications while ensuring conservation.
References
Anar M, Alpsoy L, Kizil HE, Agar G. Antigenotoxic and antioxidant activities of Anaptychia ciliaris (L.) Körb. var. ciliaris. Toxicology and Industrial Health. 2016;32(8):1401-9.
Manojlović N, Ranković B, Kosanić M, Rancić A, Stanojković T. Biological activities of the lichens Anaptychia ciliaris and Physcia aipolia. Journal of Food Science and Technology. 2024;61(2):587-96.
Sachin P, Sharma M, Kumar A, Kumar S. Insecticidal and anti-inflammatory activities of lichen extracts from Western Himalaya. Natural Product Research. 2018;32(20):2442-7.
Taş I, Akyüz S, Güllüce M, Sökmen M. Antiproliferative and antioxidant activities of extracts from lichen Anaptychia ciliaris. Pharmaceutical Biology. 2017;55(1):1165-73.
Shivanna R, Prashith Kekuda T, Mallikarjun N, Vinayaka KS, Swathi D. Biological activities of the lichen Heterodermia leucomelos (L.) Poelt. International Journal of Drug Development and Research. 2017;9(1):15-22.
Pereira EC, Mendes JM, da Silva N, de Oliveira IS, da Silva TMS, Camara CA, et al. Anti-inflammatory and antinociceptive activities of Heterodermia obscurata. Zeitschrift für Naturforschung C. 2010;65(7-8):439-46.
Musharraf SG, Uddin J, Siddiqui AJ, Rahman AU, Ali A. Screening of antimicrobial potential of selected lichen species from Pakistan. Pakistan Journal of Botany. 2015;47(2):661-7.
Bhat BA, Rather LJ, Singh P, Bhat KA. Cytotoxic and anticancer potential of Heterodermia boryi. Phytotherapy Research. 2022;36(3):1302-10.
Shivanna R, Prashith Kekuda T, Mallikarjun N, Swathi D. Antifungal potential of lichen Heterodermia comosa. International Journal of Pharmaceutical Sciences Review and Research. 2016;39(1):185-8.
Barakat H, El-Sayed NH, Abdel-Latif AS, Zaki AM. Antifungal activity of lichen Tornabea scutellifera and its chemical constituents. Mycobiology. 2023;51(1):65-73.
Albayrak S, Aksoy A, Sağlam H, Albayrak S. Antioxidant and antimicrobial activities of some lichen species. Journal of Medicinal Plants Research. 2016;10(19):255-62.
Tabarsa M, Karnjanapratum S, Cho M, You S. Bioactive compounds from marine lichens: isolation, characterization, and their biological activities. Marine Drugs. 2019;17(6):345.
Tomović J, Stanojković T, Vukojević J, Jovanović O, Ranković B, Kosanić M. Antioxidant and cytotoxic activities of selected lichens from Serbia. Journal of Food Science and Technology. 2019;56(5):2676-84.
Kerboua K, Bounar R, Benkhaled M, Sabaou N. Secondary metabolites from Physcia mediterranea and their antioxidant properties. Natural Product Research. 2021;35(18):3104-9.
Nugraha AS, Keller PA, Pyne SG. Bioactivity of Physcia millegrana extracts against human cancer cell lines. Chemistry & Biodiversity. 2019;16(8):e1900204.
Firdous S, Shahid M, Khan S, Ullah I, Ahmad W. Cytotoxic, antifungal and antibacterial activities of Physcia vitti. BMC Complementary Medicine and Therapies. 2024;24(1):215.
Zeghina O, Bensouici C, Bouchaala M, Sabaou N. Antibacterial activity of Physconia venusta extracts and chemical composition. Natural Product Research. 2024;38(4):703-10.
Noh JH, Kim JY, Kim KH. Cytotoxic and anticancer effects of Physconia hokkaidensis. Pharmaceutical Biology. 2021;59(1):1111-7.
Kandelinskaya OV, Lopatina KA, Ilyukha VA, Yakovleva EI. Determination of trace metals in Physconia hokkaidensis. Environmental Monitoring and Assessment. 2022;194(5):346.
Mugesh G. Glutathione peroxidase activity and mimics. Current Opinion in Chemical Biology. 2013;17(2):326-33.
Silva A, Oliveira PF, Soares J, Alves MG. Phenolic compounds and human health: bioavailability, mechanisms of action and biological effects. Molecules. 2018;23(6):1323.
Karak P. Biological activities of flavonoids: an overview. International Journal of Pharmaceutical Sciences and Research. 2019;10(4):1567-74.
Bhagavathy S, Sumathi P, Jancy SH. Antioxidant and antibacterial activity of chlorophyll extract from Spirulina platensis. Journal of Food Science and Technology. 2011;48(6):669-74.
Kosanić M, Ranković B, Stanojković T. Biological activities of two lichen species. Biologia. 2014;69(12):1478-86.
Marijana R, Ranković B, Kosanić M. Antimicrobial activity of the lichen compound zeorin. African Journal of Microbiology Research. 2010;4(24):2756-60.
Marković S, Ranković B, Kosanić M. Antimicrobial activity of lichen secondary metabolite lichexanthone. Journal of Food Science and Technology. 2019;56(2):875-81.
Pathak R. Antimicrobial activity of methyl-β-orcinol carboxylate. Journal of Applied Pharmaceutical Science. 2017;7(4):185-8.
Kocovic A, Vasiljevic B, Stanojkovic T. Antimicrobial, antioxidant and cytotoxic activity of obtusic acid from lichens. Natural Product Research. 2022;36(16):4193-8.
AlSalhi MS, Devanesan S, Alfuraydi AA, Ranjitsingh AJ, et al. Antimicrobial and antioxidant properties of methylbenzoic acid derivatives. Saudi Journal of Biological Sciences. 2019;26(1):105-12.
Elagbar ZA, Naik RR, Shakya AK, Bardaweel SK. Fatty acids from plant and marine sources: applications in nutraceuticals and health promotion. Journal of Lipids. 2016;2016:1-16.
Tamilarasan S, Rajendran N, Mani P. Anticancer and antibacterial activity of galactose derivatives. Journal of Applied Biomedicine. 2021;19(1):48-55.
Bilková A, Hromadková Z, Ebringerová A. Antimicrobial activity of mannose-containing polysaccharides. Carbohydrate Polymers. 2015;134:476-81.
Seedevi P, Moovendhan M, Sudharsan S, Vairamani S, Shanmugam A. Antidiabetic potential of rhamnose-rich polysaccharides. International Journal of Biological Macromolecules. 2020;150:834-43.
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