CORRELATION OF RENAL RESISTIVE INDEX WITH SERUM CREATININE AND ALBUMINURIA IN PATIENTS OF DIABETIC NEPHROPATHY
DOI:
https://doi.org/10.71000/y0j6mf59Keywords:
Hypertension, renal resistive index RRI, serum creatinine and albuminuria, diabetic nephropathyAbstract
One metabolic disease known as diabetes mellitus is typified by symptoms resulting from either incorrect insulin action, problems in internal secretion, or both. The frequency of type 2 diabetes is rising in Pakistan, and co-morbid conditions including obesity, a family history of the disease, and hypertension appear to enhance the chance of developing the condition. One severe microvascular consequence of diabetes mellitus is diabetic nephropathy. According to estimates, diabetics are significantly more likely than non-diabetics to die from renal failure.
Objective: To determine correlation of renal resistive index with serum creatinine and albuminuria in patients of diabetic nephropathy.
Methodology Setting: Department of diagnostic radiology, Combined Military Hospital Malir Study design: Cross-sectional study
Duration: 6-months after approval of synopsis.
Sample size: 190 patients was calculated through STATA 15 using formula for one sample correlation. The study was conducted after permission from ethical review committee. A total of 190 patients referred to diagnostic radiology department for ultrasound KUB/abdomen, fulfilling the inclusion criteria, were enrolled after informed consent. The baseline characteristics including age, gender, duration of diabetes, hypertension and smoking were recorded. A real-time B-scan were used to view the kidneys first, followed by a duplex Doppler ultrasonography to check the intrarenal arteries. Each kidney's upper, middle, and lower intrarenal arteries had at least three measurements made. The machine used a predefined calculation to determine the RI value.
Results: There were 85 (44.7%) females and 105 (55.3%) males. Hypertension was reported by 68.9% of respondents. Smoking prevalence was lower, with 37.4%. The average duration of diabetes is 8.6 ± 2.5 years, with a range of 5 to 15 years. A measure of kidney vascular resistance, the renal resistive index (RRI) has a mean of 0.71 ± 0.04 and a narrow range of 0.60 to 0.80.
Conclusion: It is concluded, our study supports the use of RRI as a valuable, non-invasive marker that correlates well with serum creatinine and albuminuria in diabetic nephropathy.
References
Zafar J, Bhatti F, Akhtar N, Rasheed U, Bashir R, Humayun S, et al. Prevalence and risk factors for diabetes mellitus in a selected urban population of a city in Punjab. J Pak Med Assoc 2011; 61(1): 40-47.
International Diabetes Federation. IDF Diabetes Atlas, 6th ed. Brussels, Belgium: International Diabetes Federation, 2013.
Meo SA, Zia I, Bukhari IA, Arain SA. Type 2 diabetes mellitus in Pakistan. Current prevalence and future forecast. J Pak Med Assoc 2016; 66(12): 1637-42.
Birkeland KI, Bodegard J, Eriksson JW, Norhammar A, Haller H, Linssen GC, et al. Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: a large multinational cohort study. Diabetes Obes Metab. 2020;22(9):1607-18.
Duan JY, Duan GC, Wang CJ, Liu DW, Qiao YJ, Pan SK. Prevalence and risk factors of chronic kidney disease and diabetic kidney disease in a central Chinese urban population: a cross-sectional survey. BMC Nephrol. 2020;21(1):115.
McGrath K, Edi R. Diabetic kidney disease: diagnosis, treatment, and prevention. Am Fam Physician. 2019;99(12):751-9.
Valma H, Per-Henrik G. Epidemiology and Risk Factors for Diabetic Kidney Disease. Adv Chronic Kidney Dis 2014; 21(3): 260-66.
Radica Z, Michele T, Katherine R. Diabetic kidney disease challenges, prog
Jinadu YO, Raji YR, Ajayi SO, Salako BL, Arije A, Kadiri S. Resistivity index in the diagnosis and assessment of loss of renal function in diabetic nephropathy. Cardiovasc J Afr. 2022;33(1):26-32.
Elshweehy SA, Mohammed HA, Osama SM. Role of duplex doppler ultrasound in evaluation of patients with diabetic nephropathy. Sci J Al-Azhar Med Faculty Girls. 2020;4(3):456-62.
Jung SI, Moon MH, Sung CK, Lee MS, Park JH, Oh S. Renal Doppler ultrasonography for predicting non-diabetic kidney disease in patients with diabetes. Ultrasonography. 2023;42(3):440-5.
Cafarotti A, Marcovecchio ML, Lapergola G, Di Battista C, Marsili M, Basilico R, et al. Kidney function and renal resistive index in children with juvenile idiopathic arthritis. Clin Exp Med. 2023;23(3):759-66.
Shirin M, Sharif MM, Gurung A, Datta A. Resistive index of intrarenal artery in evaluation of diabetic nephropathy. Bangladesh Med Res Counc Bull. 2015;41(3):125-30.
Radermacher, J., Ellis, S., & Haller, H. (2002). Renal resistance index and renal function in renal artery stenosis. New England Journal of Medicine, 347(9), 621–627. https://doi.org/10.1056/NEJMoa020143
Sugiura, T., & Wada, A. (2011). Resistive index predicts renal prognosis in chronic kidney disease. Clinical and Experimental Nephrology, 15(5), 694–700. https://doi.org/10.1007/s10157-011-0455-3
Nosadini, R., Velussi, M., Brocco, E., et al. (2000). Increased renal arterial resistance predicts the course of renal function in type 2 diabetes with microalbuminuria. Diabetes, 49(3), 476–482. https://doi.org/10.2337/diabetes.49.3.476
Tublin, M. E., Bude, R. O., & Platt, J. F. (2003). The resistive index in renal Doppler sonography: Where do we stand? AJR. American Journal of Roentgenology, 180(4), 885–892. https://doi.org/10.2214/ajr.180.4.1800885
Granata, A., Clementi, S., Londrino, F., et al. (2016). Doppler ultrasound and renal resistive index: An early marker of chronic kidney disease progression. Journal of Clinical Medicine, 5(4), 41. https://doi.org/10.3390/jcm5040041
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